Thought this may be relevant to biosensing community!
Just came across this fascinating paper in PNAS on copper free click chemistry for imaging in laboratory mouse. For people unfamiliar with click chemistry there are several excellent paper available free online-just search Google Scholar. Though click chemistry has been used fairly regularly for surface chemistry and biosensing related applications, labeling proteins in-vivo in cells/animals opens up whole new avenue for various biosensing platforms. Protein-protein and protein-DNA interaction studies come to mind right away. Glycomics is another.