Print-and-Peel for Biosensors

I have a confession to make! I had never heard of phrase “Print-and-Peel” until today. I spend considerable amount of time keeping up-to-date with the literature but somehow “Print-and-Peel” escaped me till I came across this wonderful review in recent issue on Annals of Biomedical Research: “Print-and-Peel Fabrication for Microfluidics: What’s in it for Biomedical Applications?” I am aware of PDMS technology and Shrinky Dink Microfluidics and associated technology but don’t know when the catch phrase “Print-and-Peel (PAP)” was invented.

Now that I know the PAP technology I can appreciate the paper just published by Prof. Craighead on using PAP for printing protein arrays.

Credit: Nano Lett., DOI: 10.1021/nl903968s

As for utility of protein nanoarrays in real world application-that’s topic for another discussion. Suffice to say that key bottleneck for protein arrays is not the printing technology but getting access to high purity protein content that can be patterned on surfaces and can still maintain their functionality. Mike Snyder, Josh Labaer, Gavin Macbeath all have developed and used protein arrays with thousands of proteins at the surface for research purposes but most of the protein based multiplexed assays for diagnostic research still use numbers in single digits or low double digits.

Do you foresee a place for commercial diagnostic kits with thousands of proteins? Let me know!


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