If I have to single out one critical component that can make or break a biosensor it will be the functional immobilization of biomolecules. So when I came across a recent article on designing nanostructured films by self assembly of amyloidogenic proteins my first thought was that these films may be useful as support for capturing proteins/cells. As I learned “Amyloidogenic proteins are polypeptide molecules capable of self-assembly into β-sheet rich linear aggregates; such structures were first discovered in association with range of disease state”. The films were created using Hen egg white lysozyme and β-lactoglobulin and took several days of multistep processing. The hydrogel like films could be cut using a razor blade for any downstream application. For biosensing applications, I assume various biomolecules could be trapped in these films and hydrogel like environment should be maintain the functionality and enhance the shelf life.
Eventhough for now the processing time is impractical for commercial applications but further process improvements should simplify the things. Neat stuff!